Pfizer Added Tromethamine To COVID-19 Vaccine For Kids?!

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Did Pfizer secretly add Tromethamine – a “heart attack drug” also known as Tris – to their COVID-19 vaccine for kids?!

Take a look at the viral claim, and find out what the FACTS really are!


Claim : Pfizer Secretly Added Tromethamine To COVID-19 Vaccine For Kids!

The Alex Jones Show, The Expose UK, Infowars, Natural News and other anti-vaccination websites have been pushing the claim that Pfizer secretly added Tromethamine to their newly-approved COVID-19 vaccine for kids!

They claimed that Pfizer added Tromethamine to their COVID-19 vaccine for kids, to reduce the risk of children getting heart attacks as a side effect.

A newly released document shows that drug giant Pfizer added a secret heart attack drug to the children’s version of its Wuhan coronavirus (COVID-19) vaccine.

The Food and Drug Administration (FDA) Advisory Committee that voted 17-0 to approve the jabs for children as young as five was notified that the children’s formulation of the drug contains tromethamine (Tris), a chemical that reduces blood acidity and stabilizes people who have suffered a heart attack.

Here are known side effects: Respiratory depression – local irritation- tissue inflammation – injection site infection – febrile response – chemical phlebitis – venospasm (vein spasms) – hypervolemia – IV thrombosis – extravasation (with possible necrosis and sloughing of tissues) – transient decreases in blood glucose concentrations – hypoglycemia, and Hepatic Necrosis with infusion via low-lying umbilical venous catheters.

Recommended : New Study Proves Pfizer mRNA Vaccine Causes Turbo Cancer?!

Did Pfizer Secretly Add Tromethamine To COVID-19 Vaccine For Kids?


Truth : Pfizer Did NOT Secretly Add Tromethamine To COVID-19 Vaccine For Kids!

This is yet another example of vaccine FAKE NEWS being created and propagated by anti-vaxxers to discourage the vaccination of children.

Pfizer did NOT “secretly” add Tromethamine to their newly-approved COVID-19 vaccine for children to reduce or prevent the risk of heart attacks in children.

Everything posted by Alex Jones, Infowars, Natural News or The Expose UK, must be regarded as FAKE NEWS, until proven otherwise.

For those who want more information on why this is false, here are the reasons…

Fact #1 : It Was Public Information

Anti-vaccination websites and supporters are FALSELY claiming that Pfizer SECRETLY added Tromethamine (Tris) to the new paediatric COVID-19 vaccine.

The truth is – that was PUBLICLY AVAILABLE information that Pfizer and US FDA released in page 12 of the VRBPAC briefing document on 22 October 2021!

Pfizer/BioNTech are requesting authorization of a modified formulation of BNT162b2 to accommodate the 10-µg dose.

This modified formulation allows for an improved stability profile and greater ease of use at administration sites. The modified formulation uses a Tris buffer instead of phosphate-buffered saline (PBS) and excludes sodium chloride and potassium chloride.

Authorization and future licensure of the modified formulation is based on analytical comparability to the currently authorized PBS containing formulation in accordance with CBER guidance. The change in buffer is not considered clinically significant.

By lying that it was a secret, they are trying to fool you into thinking that Pfizer was trying to slip tromethamine into the paediatric vaccine without the US FDA or the public knowing about it.

That’s not only easily proven false, it is intentionally deceitful.

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Did Pfizer Add Heart Attack Drug To COVID Vaccine For Kids?

Fact #2 : Tromethamine Used To Stabilise Paediatric Pfizer Vaccine

By replacing the original phosphate-buffered saline in the new paediatric COVID-19 vaccine, it can now be stored in a normal refrigerator at 2-8°C for up to 10 weeks.

That is a HUGE 2.5X improvement over the current storage limit of the Pfizer COVID-19 vaccine :

  • originally, the vaccine could only be stored between 2-8°C for up to 5 days.
  • after further stability tests, the US FDA determined on 19 May 2021 that it can be stored between 2-8°C for up to 31 days.

There are no other changes to the vaccine, so only the change in the buffer could have accounted for the big jump in vaccine stability and longer storage time.

Fact #3 : Tromethamine Is NOT A Heart Attack Drug

Tris, which is short for tris(hydroxymethyl)aminomethane or tromethamine / trometamol / THAM in medical use, is an organic compound with MANY uses.

In biochemistry and molecular biology, it is used in buffer solutions (to maintain pH level) especially when there is a need to stabilise nucleic acids.

In medical use, Tris is used to treat metabolic acidosis, as an alternative to sodium bicarbonate. That’s its purpose in cardiac bypass surgery – to correct metabolic acidosis that may occur during or immediately after surgery.

Tromethamine is NOT a drug that treats heart attack. Neither is it capable of preventing heart attacks. So the claim is completely false and nonsensical.

If Tromethamine can actually prevent myocarditis / pericarditis, it would have been added to the Pfizer vaccine for adults and adolescents long ago.

Fact #4 : Tromethamine Is Used In The Moderna COVID-19 Vaccine

The Moderna COVID-19 vaccine has been using Tris or tromethamine as a buffer from the very beginning, to maintain its pH level and stabilise the nucleic acid macromolecules.

If Tris / Trometamol / Tromethamine is truly being added to prevent heart problems as a side effect, then the Moderna vaccine would not have the same problem with myocarditis or pericarditis.

Yet, the Moderna vaccine can similarly cause myocarditis / pericarditis in young males, just like the Pfizer vaccine.

This shows that Tris / Trometamol / Tromethamine has ZERO effect on heart problems.

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Pfizer vs Moderna vaccine content

Fact #5 : Only 0.15 mg Of Tromethamine In Each Dose

Each dose of the Pfizer paediatric COVID-19 vaccine contains 0.02 mg tromethamine and 0.13 mg of tromethamine hydrochloride.

For simplicity’s sake – that’s a total of 0.15 mg of Tromethamine in a single shot. There is 6X more sodium chloride (0.9 mg) than Tromethamine in that shot.

The maximum dose for tromethamine is 500 mg/kg when taken within an hour. A typical 5 year-old child weighs about 18 kg, so we should not exceed 9,000 mg or 9 grams.

In other words – the 0.15 mg of tromethamine in that Pfizer vaccine dose is just 0.00167% of the maximum dose a 5 year-old child can receive.

Fact #6 : Tromethamine Can Be Injected Intramuscularly

Many Google doctors who looked up tromethamine in the use of metabolic acidosis will see that it is usually administered intravenously, and immediately insist that it can only be administered intravenously.

That’s not true. For example, ketorolac tromethamine can either be injected intravenously or intramuscularly. Heck, it even comes in the form of eye drops and oral tablets!

It all depends on what it’s used for, and its formulation.

Recommended : Did US FDA Just Ban Pfizer + Moderna Vaccines?!

Ketorolac tromethamine injection

Fact #7 : Myocarditis / Pericarditis Is NOT Heart Attack

Antivaxxers are trying to conflate the existing myocarditis / pericarditis adverse effect, with a myocardial infarction (heart attack). They are completely different.

Myocarditis / pericarditis is the INFLAMMATION of the heart muscle (myocarditis) or outer lining of the heart (pericarditis), causing chest pain, shortness of breath or feelings of a pounding or fast-beating heart.

It is generally mild, and most will respond well to medicine and rest, and recover completely. They can usually return to normal daily activities once their symptoms improve / resolve.

Myocardial infarction is the IRREVERSIBLE DEATH of the heart muscle due to a PROLONGED LACK of oxygen supply. This is a medical emergency which will result in death if not treated quickly.

Individuals who survive a myocardial infarction will not recover completely, because you cannot restore the dead heart muscle.

Recommended : Do mRNA Vaccines Increase Risk Of Death + Injuries?!

Did Pfizer Add Heart Attack Drug To COVID Vaccine For Kids?

Fact #8 : COVID-19 Causes More Myocarditis / Pericarditis Than Vaccines

The adult dose of the Pfizer COVID-19 vaccine has a rare risk of causing myocarditis or pericarditis in adolescents and young males., but the paediatric Pfizer vaccine has SO FAR not caused any case of myocarditis or pericarditis.

However, what antivaxxers won’t tell you is that COVID-19 itself causes way more cases of myocarditis or pericarditis than the Pfizer vaccine!

For a better perspective of the risk of developing myocarditis, I created this comparison table for you :

Myocarditis Risk Per Million People Difference
COVID-19 Patient 450 +2208%
Pfizer Vaccine
(Adult Dose)
20 +2.6%
Normal Population 19.5 Baseline

As you can see, the risk of developing myocarditis is MUCH higher if your child gets infected with COVID-19, compared with getting a full dose of the Pfizer vaccine.

I have no idea if the myocarditis risk is truly lower with the paediatric dose, but it surely cannot be more than the full dose that is currently being administered to adolescents.

Read more : Pfizer COVID-19 Vaccine For Kids : What You Need To Know!

Did Pfizer Add Heart Attack Drug To COVID Vaccine For Kids?


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Dr. Adrian Wong has been writing about tech and science since 1997, even publishing a book with Prentice Hall called Breaking Through The BIOS Barrier (ISBN 978-0131455368) while in medical school.

He continues to devote countless hours every day writing about tech, medicine and science, in his pursuit of facts in a post-truth world.


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