Can Pfizer Vaccine Cause Prion / Alzheimer’s Disease?!

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Can the Pfizer mRNA vaccine cause prion and neurological diseases like ALS and Alzheimer’s disease, as the Classen study claims?

Find out what the Classen study is all about, and whether the Pfizer mRNA vaccine can really cause prion diseases!


Classen Study : Pfizer Vaccine Can Potentially Induce Prion Disease

The journal Microbiology & Infectious Diseases just published a “research article” by J. Bart Classen, MD of Classen Immunotherapies.

This paper claims to have found that the Pfizer mRNA vaccine could potentially induce prion disease that would lead to the development of common neurodegenerative diseases like ALS and Alzheimer’s disease.


Now, take a minute to let the shock and horror subside, before you read on and find out what the facts really are…

Was Pfizer Vaccine Confirmed To Cause Prion Diseases?


Pfizer mRNA Vaccine Does NOT Cause Prion / Alzheimer’s Disease!

Here is the short version – there is no evidence that mRNA vaccines cause prion or neurological diseases like Alzheimer’s or ALS.

The truth is – the Classen study is not even a “study”, much less a research paper. It is just a 2.5-page opinion piece that makes a lot of bombastic claims, with ZERO evidence to back them up.

Unsurprisingly, it is only published in Microbiology & Infectious Diseases. Sounds impressive, but it is “not a reputable or reliable journal“, as Georgetown University virologist, Dr. Angela Rasmussen notes.

Dr. David Gorski, professor of surgery and oncology at Wayne State University concurred, pointing out that Microbiology & Infectious Diseases is listed in the Beall’s list of predatory publishers, and is not even indexed in PubMed.

But let’s go through J. Bart Classen’s claims, and find out what the facts really are…

Was Pfizer Vaccine Confirmed To Cause Prion Diseases?

Fact #1 : Prion Diseases Are Transmissible Misfolded Proteins

Prion diseases are transmissible spongiform encephalopathies (TSEs) – brain disorders caused by prion proteins.

These are basically misfolded proteins that causes other proteins to fold themselves into the same shape.

Think of the prion protein as Agent Smith in Matrix Revolution, turning everyone he touches into a clone of himself.

Most people will have heard of Mad Cow Disease – Bovine Spongiform Encephalopathy (BSE), and you may have heard of the Creutzfeldt-Jakob disease and Kuru. These are all prion diseases.

Fact #2 : The Spike Protein Is From The SARS-CoV-2 Virus

The spike protein is both the “uniform” and the “weapon” of the SARS-CoV-2 virus.

The crown (corona) of protein spikes is what gives the virus family its distinctive appearance and name – coronavirus, and it is how the virus attaches to our cells and gains entry.

If the SARS-CoV-2 spike protein truly has multiple binding areas that can create prion proteins, then the virus itself would actually cause prion diseases!

As of 8 May 2021, there have been over 161 million cases of COVID-19 globally, with over 3.34 million deaths.

There have been ZERO cases of prion diseases associated with COVID-19 infections.

Recommended : Did Salk Institute Prove Covid-19 Vaccines Cause Blood Clots?

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Fact #3 : Many COVID-19 Vaccines Use The Spike Protein

It is odd that Classen would focus on RNA-based vaccines, particularly Pfizer. After all, many other COVID-19 vaccines also target the spike protein.

As I pointed out in my earlier article, many COVID-19 vaccines are designed to specifically target the spike protein because :

  • it is the defining feature of the SARS-CoV-2 virus
  • antibodies targeting it will block the virus from binding with our cells

If Classen is correct that the spike protein induces prion disease, then it would be true of ALL vaccines that mimic the spike protein.

Yet, after over 680 million doses of COVID-19 vaccines have been administered (as of 13 May 2021), there have been ZERO reports of prion disease associated with any COVID-19 vaccine.

Fact #4 : RNA Binding Protein Is Not RNA / mRNA

Classen used this 2012 study to push the narrative that RNA binding proteins have been “shown” to cause “a number of neurological diseases including Alzheimer’s disease and ALS”, specifically TDP-43 and FUS.

The trouble is the study he used did not actually prove that those RNA binding proteins cause prion disease, much less Alzheimer’s disease or ALS or any other neurological disorders.

The study merely used an algorithm to “scour the human genome” to identify “RNA-binding prion candidates” for further investigations.

More importantly though – the study he referred to identified RNA binding proteins with prion-like domains, not RNA and certainly not mRNA  which is used in … tadaa… mRNA vaccines.

That is like saying that since some dog breeds are potentially dangerous, cats and hamsters are therefore also potentially dangerous. Really???

Fact #5 : mRNA Vaccines Do NOT Enter Our Cell Nucleus

I have pointed this out many times before – the mRNA instructions in the Pfizer and Moderna mRNA vaccines do NOT enter the cell nucleus (where our DNA resides).

They are only read and used by the cell ribosomes in the cytoplasm (outside of the nucleus) to create the spike proteins, before being discarded.

This point is important because the two RNA binding proteins that Classen kept pointing out either predominantly exists in the nucleus (TDP-43) or can only be found inside the nucleus (FUS).

How is it possible for mRNA or the spike protein it creates interact with TDP-43 or FUS inside the cell nucleus, if they never enter the “locked room” that is the cell nucleus?

Fact #6 : Vaccine Spike Protein Do NOT Bind With ACE2 Receptor

After our cell ribosomes create the spike proteins, they are presented on the cell surface, to trigger the immune system.

These faux spike proteins do NOT bind with the ACE2 receptor, since they are actually part of the same cell surface as the ACE2 receptor.

Only the spike protein of a real SARS-CoV-2 virus will actually bind with the ACE2 receptor, in order to infect the cell.

ACE2 receptor and SARS-CoV-2
Credit : The Conversation

Fact #7 : No Evidence Zinc Causes TDP-43 To Go Prion

There is simply no evidence that a zinc ion turns on TDP-43’s “pathologic prion transformation”.

Plus, zinc ions exist in all our cells – it is critical for cell division and growth, and our immune system.

These zinc ions would have turned on TDP-43’s prion tendencies long before any SARS-CoV-2 spike protein comes close to the ACE2 receptor!

Fact #8 : ACE2 Receptor Is On The Cell Surface…

As Dr. David Gorski brilliantly points out, the ACE2 receptor is on the cell surface, while the TDP-43 exists in the cell nucleus.

Think of the ACE2 receptor as the door to your house, and the TDP-43 is inside your locked bedroom. How does the zinc ion fly from the main door up the stairs, through the locked door into your bedroom?

By magic? Unfortunately, Classen did not elaborate how this miracle was achieved.


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Dr. Adrian Wong has been writing about tech and science since 1997, even publishing a book with Prentice Hall called Breaking Through The BIOS Barrier (ISBN 978-0131455368) while in medical school.

He continues to devote countless hours every day writing about tech, medicine and science, in his pursuit of facts in a post-truth world.


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