Booster Dose Strategy For Shorter AstraZeneca Dose Interval

If you are worried about the LOWER EFFICACY from the shorter AstraZeneca dose interval, consider this booster dose strategy!


Shorter AstraZeneca Dose Interval : Lower Efficacy Worries

With health authorities reducing the AstraZeneca dose interval, people are now worried that it will reduce the vaccine’s efficacy.

Now, it is true that reducing the dose interval reduces the efficacy of the AstraZeneca vaccine.

Second Dose
Efficacy Efficacy Efficacy Range
≥ 12 Weeks 81.3% Baseline 60.3% to 91.2%
9 – 11 Weeks 63.7% -21.6% 28.0% to 81.7%
6 – 8 Weeks 59.9% -26.9% 32.0% to 76.4%
< 6 Weeks 55.1% -32.2% 33.0% to 69.9%

So why are health authorities reducing the dose interval?

That’s because the Delta variant is raging across the world, and a single dose of the AstraZeneca vaccine offers poor protection against it.

1 Dose 2 Doses 1 Dose 2 Doses
Alpha (UK) 50% 66% 76% 86%
Delta (India) 33% 60% 71% 92%

Now, let me share with you the booster dose strategy that could allay your fears of lower efficacy from the shorter AstraZeneca vaccine dose interval.


Booster Dose Strategy For Shorter AstraZeneca Dose Interval

First of all, do not panic about the lower vaccine efficacy from a shorter dose interval.

There’s no point in delaying the dose interval for higher efficacy, if you get infected before you have the chance to get the second dose!

If you are a young healthy adult who can work from home for 12 whole weeks, you can try delaying your second dose for higher efficacy.

But most of us probably don’t have that luxury, so sacrificing a little efficacy for earlier protection against the Delta variant makes sense.

The good news is you can always improve your protection against COVID-19, by getting a third booster dose later.

Now, I do not know if the health authorities will approve a free third dose, but COVID-19 vaccines will soon be available for sale.

As long as you are prepared to pay for this third dose – preferably an mRNA vaccine – you will be able to greatly improve your protection against COVID-19.

This is one way you can get early protection against the Delta variant, without worrying too much about losing vaccine efficacy from the shorter dose interval.

Of course, we hope that health authorities will look at implementing heterologous vaccination – mixing AstraZeneca with Pfizer for example – for better protection through only two vaccine doses.


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